![]() According to the Centers for Disease Control and Prevention (CDC), occasional use of common OTC sleep aids like Unisom (doxylamine) and Benadryl (diphenhydramine) has not been linked to birth defects. Over-the-counter (OTC) sleep aids: About 10%–15% of people take antihistamines at some point during pregnancy, often to promote sleep. ![]() Nightmares are especially common during the third trimester and just before childbirth.
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